We have seen consistent crashes in Pro Tools sessions for users running Pro Tools version 2021.10 or older on systems running Mac OS 12. This issue is related to incompatibility between Pro Tools versions 2021.10 and older and Mac OS 12 Monterey, as the crashes occur with iZotope products that are fully compatible with OS 12.
Updating to Pro Tools 2021.12 or newer has resolved these crashes, as the newer Pro Tools versions are compatible with OS 12 Monterey.
You can see the Pro Tools compatibility chart on this page here: https://avid.secure.force.com/pkb/articles/en_US/compatibility/Pro-Tools-Operating-System-Compatibility-Chart
We are truly sorry for any inconvenience, and please do not hesitate to reach out to iZotope Customer Care if you have any questions or are experiencing further issues.